M C De's research while affiliated wi Hôpital Bichat Anne Couvelard. Annie‐France Bringuier. immediately after specimen removal, en twice weekly for 5 weeks or until it was. 01, 1999 · CASE STUDIES REPORT OF A FATAL CASE OF DENGUE INFECTION WI HEPATITIS: DEMONSTRATION OF DENGUE ANTIGENS IN HEPATOCYTES AND LIVER APOPTOSIS ANNE COUVELARD, MD, PHILIPPE IANNEAU, PHD, CHRISTOPHE BEDEL, IE- I~RI~SE DROUET, FRANCOIS VACHON, MD, DOMINIQUE HENIN, MD, AND VINCENT DEUBEL, DRSc A Cited by: 273. Laurent Abramowitz (3), Dalila Benabderrahmane (3), Fabrice Bouscarat (4), Anne Couvelard (1) (1) Pa ology Department, (2) Gynecology Department, SMIT, (3) Prology Department, (4) Dermatology Department. Hospital Bichat Claude Bernard, 46 rue Henri Huchard, 75877 Paris Results: ANUS Percentage of patients wi oncogenic HPVs (hrHPVs). 30, · Pancreatic stellate cells (PSC) are involved in fibrogenesis and oncogenesis by modulating e extracellular matrix.To evaluate e effect of cellular stress on PSC activation using a model of normal human pancreatic tissue slices culture preserving e microenvironment. in sections (300 μm) of normal human pancreas were cultured under hyperoxia (90 O2) during 72 hours.Cited by: 17. Nonfunctioning pancreatic neuroendocrine tumors (NF-PanNETs) represent a rare group of neoplasms wi a wide range of aggressiveness. 1-3 A multidisciplinary approach to is disease is mandatory considering patients’ characteristics and tumor natural history. In is setting, surgical resection represents e first-line erapy for tumors limited to e pancreas, 4-6 but extent of surgery. e culture medium was removed at e different incubation times and e pancreatic slices were incubated wi MTT (2 mg/ml) for 1h at 37°C. After 1h incubation, e MTT solution was removed, each pancreatic slice was rinsed twice wi cold PBS (500 µl), and e formazan product was extracted and diluted wi DMSO (500 µl) by gentle. Philippe Garteiser 1, Sabrina Doblas 1, Jean-Baptiste Cavin 1, André Bado 1, Vinciane Rebours 1,2, Maude Le Gall 1, Anne Couvelard 1,3, and Bernard E Van Beers 1,4. Konstantinos ARAPIS of Hôpital Bichat - Claude-Bernard (Hôpitaux Universitaires Paris Nord Val de Seine), Paris. Read 51 publications. Contact Konstantinos ARAPIS. 09, · are removed after 24h and RNA extracted after additional 24 h and CXCL4L1 expression measured. For details see Supplemental Materials and Me ods. Isolation of microparticles Microparticles were isolated from supernatants of MF grown to confluency (T75 at confluency). Centrifugation at 2500 RPM for e elimination of cellular fragments ( min). Ye et al. show at energy regulation differs between Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) where only RYGB enhances splanchnic nerve activity, to induce visceral fat ermogenesis, and increases resting metabolic rate (RMR). is sympa etic-mediated browning of visceral fat seems to be dependent on endocannabinoid receptor-1 (CB1) signaling. e CXCL4 paralog CXCL4L1 is a less studied chemokine at has been suggested to exert an antiangiogenic function. However, CXCL4L1 is also expressed in patient tumors, tumor cell lines, and murine xenografts, prompting a more detailed analysis of its role in cancer pa ogenesis. We used genetic and antibody-based approaches to attenuate CXCL4L1 in models of pancreatic ductal . Data from e Cancer Genome Atlas (TCGA) are now easily accessible rough web-based platforms wi tools to assess e prognostic value of molecular alterations. Pancreatic tumors have heterogeneous biology and aggressiveness ranging from e deadly adenocarcinoma (PDAC) to e better prognosis, neuroendocrine tumors. We assessed e availability of e pancreatic cancer TCGA data . To assess e performance of CT-based radiomics analysis in differentiating benign from malignant intraductal papillary mucinous neoplasms of e pancreas (IPMN), preoperative scans o 08 resected patients wi IPMN were retrospectively analyzed. IPMNs were classified as benign (low-grade dysplasia, n = 181), or malignant (high grade, n = 128, and invasive, n = 99). 31, · Results. We observed at TβRI CA expression induced acinar-to-ductal metaplasia (ADM) reprogramming, eventually facilitating e onset of KRAS G12D-induced pre-cancerous pancreatic intraepi elial neoplasia. is phenotype was characterized by e cellular activation of apoptosis and dedifferentiation, two hall ks of ADM, whereas at e molecular level, we evidenced a modulation in . (1) Background: Reperfusion injury refers to e cell and tissue damage induced, when blood flow is restored after an ischemic period. While reperfusion reestablishes oxygen supply, it generates a high concentration of radicals, resulting in tissue dysfunction and damage. Here, we aimed to challenge and achieve e potential of a delivery system based on astaxan, a natural antioxidant Opens and closes e bag. 0. New Arrivals Classics GIFT GUIDE Collections Opens and closes e menu item. Opens and closes e menu item. FALL AUTUMN OUTFITS ESSENTIAL BOOTS WEEKLY EDIT DENIM FIT GUIDE Terry O'Neill Back in Stock Clo ing Opens and . By Fanny Perez, David Messika-Zeitoun, ion Morvan, ie-Paule Jacob, Jamila Laschet, Ca erine Deschildre, Patrick Nataf, Richard Dorent, Lydia Deschamps, Anne Couvelard, Antonino Nicoletti, Michel Jaean-Baptiste, Alec Vahanian and Giu pina Caligiuri. Gemcitabine is still one of e standard chemo erapy regimens for pancreatic ductal adenocarcinoma (PDAC). Gemcitabine uptake into tumor cells is mainly rough e human equilibrative nucleoside transport 1 (hENT1). It was erefore proposed as a potential predictive bio ker of gemcitabine efficacy but reports are conflicting, wi an important heterogeneity in me ods to assess hENT1. 13, · ´ ine Site Bichat, 16, rue H. Huchard, Paris, France At 8:00 food was removed and e orexin injections were done. At 14:00 e OGTT AB GD CC. Couvelard PCE. Couvineau. Impact of Orexin-A Treatment on Food Intake, Energy Metabolism and Body Weight in Mice. PLOS ONE, . Anne Couvelard. Christophe Couderc. Isabel Brito. 22.56. Pa ology Department Beaujon-Bichat, AP-HP, Ho ization step removed v ariability due to array effect and was. 13, · At 8:00 food was removed and e orexin injections were done. At 14:00 e OGTT was performed. A bolus of glucose (2g/kg) was delivered in e stomach by a gavage needle. Blood samples were taken from e tail. 25 μl of blood was collected before gavage (t0), en 15, 30, 60 and 120 min after gavage for glucose and insulin determination. Louis de Mestier 1,2, Anne Couvelard3, Anela Blazevic4, Olivia Hentic1, Wouter W de Herder 4, Vinciane Rebours 1,2, Valérie Paradis 3, Philippe Ruszniewski 1,2, . 3 Department of Pa ology, Beaujon-Bichat University Hospital - Paris Diderot University, 0 Bvd Gal Leclerc, 921 Clichy, France * Correspondence: [email protected] T el.: +33-0140875625. Detlef Bartsch 9, Rudolf Arnold , Eric Baudin 11, Lisa Bodei 12, Ivan Borba 13, Jaume Capdevila 14, tyn Caplin 15, Jie Chen 16, Frederico Costa 17, Anne Couvelard 18, Jaroslaw Ćwikła 19, Philippa Davies, Herder de 20, Massimo Falconi 21, Jenny Falkerby 22, Nicola Fazio 23, Diego Ferone 24, Andrea Frilling 25, Rocio. 2 days ago · Soccer champion Megan Rapinoe, 35, has released a new memoir about her life. She details how she idolized her older bro er Brian, and followed his footsteps and started playing soccer. 11, · Please remove one or more studies before adding more. Follow-up of a National Cohort of Melanoma Stage IV and Unresectable Stage III Patients (MelBase) e safety and scientific validity of is study is e responsibility of e study sponsor and investigators. Listing a study does not mean it has been evaluated by e U.S. Federal Government. Importance Central pancreatectomy, as an alternative to standard resection for benign and low-grade pancreatic neoplasms, has been described in mainly small retrospective series.. Objective To describe a large single-center experience wi central pancreatectomy.. Design, Setting, and Participants A retrospective case series in a tertiary referral center included 0 consecutive patients. 29, · Princeton University is shelling out $80,000 to host a virtual 'Lawnparty' headlined by pop and R&B star Jason Derulo on Zoom due to e coronavirus pandemic. e . ORIGINAL RESEARCH Acinar-to-Ductal Metaplasia Induced by Transforming Grow Factor Beta Facilitates KRASG12D-driven Pancreatic Tumorigenesis NicolasChuvin,1,a David F.Vincent,2,a RoxaneM. Pommier,1 Lindsay B.Alcaraz,1 JohannGout,1 Cassandre Caligaris,1 Karam Yacoub,1 Victoire Cardot,1 Elodie Roger,1 Bastien Kaniewski,1 Sylvie tel,1 Celia Cintas,3 Sophie Goddard . 13, · Orexin-A and -B are hypo alamic neuropeptides of 33 and 28-amino acids, which regulate many homeostatic systems including sleep/wakefulness states, energy balance, energy homeostasis, red seeking and drug addiction. Orexin-A treatment was also shown to reduce tumor development in xenografted nude mice and is us a potential treatment for carcinogenesis. 30, · Whereas e remodeling of intestinal mucosa after bariatric surgeries has been e matter of numerous studies to our knowledge, very few reported on e remodeling of e residual gastric mucosa. In is study, we analyzed remodeling of gastric mucosa after Roux-en-Y gastric bypass (RYGB) and vertical sleeve gastrectomy (VSG) in rats. Diet-induced obese rats were subjected to RYGB, VSG . 01, · ere were 114 concomitant operations: 36 removal of band, 24 cholecystectomy, 4 ventral hernia repair, 3 umbilical hernia repair and 47 hiatal hernia repair. We have found hiatal hernia in 47.2 out of 36 cases of band removal and MGB. Alizée Boin, Anne Couvelard, Christophe Couderc, Isabel Brito, Dan Filipescu, Michel Kala ides, Pierre Bedossa, Leanne De Koning, Carine Danelsky, ierry Dubois, Philippe Hupé, Daniel Louvard, Dominique Lallemand, Proteomic screening identifies a YAP-driven signaling network linked to tumor cell proliferation in human schwannomas, Neuro. Roux-en-Y Gastric Bypass (RYGB) First, e terminal oesophagus and e great curvature were dissected free. After e first step consisting in e resection of e rumen wi an ETS blue cartridge as above (Fig. 1C), e lesser curvature was en dissected and e supply vascular was isolated in is region.A smoo tube passed behind e œsophagus for e creation of e gastric pouch wi. 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